International Conference on Cardiology, Indian Institute of Science, Bengaluru, India.
16th April 2020 at J.N.TATA Auditorium,
Indian Institute of Science, Bengaluru, Karnataka, India.
The Workshop on Robotic Cardiac Surgery will offer extensive hands-on procedural experience in a state-of-the-art robotics training facility. Specially designed for surgical teams—a surgeon and a bedside assistant or other surgical team member—the Workshop will put participants in a realistic, cardiac robotics simulation environment where they can hone their skills in mitral valve repair, coronary bypass, and other cardiac surgery procedures.
The participants should be able to:
The designed for the entire cardiac surgical team, including cardiothoracic surgeons with their bedside assistants, physician assistants, nurse practitioners, operating room staff, cardiac anesthesiologists, perfusionists, and others involved with cardiac robotic surgeries.
Dr. Vivek Jawali is Chief Cardiothoracic & Vascular Surgeon and as a Chairman, he heads the Department of Cardio Vascular Sciences at Fortis Hospitals, Bangalore. He is a pioneer in Minimally Invasive Cardiac Surgery in India and has performed over 18, 000 Cardiothoracic & Vascular surgeries till date. He performed India's first beating heart bypass surgery in 1992 and performed India's first Minimally Invasive Bypass Surgery (MIDCAB) in Sept 199 Dr. Jawali did India's first Awake Cardiac Surgery (surgery without GA or Ventilator, done under continuous high thoracic epidural) in June 1999. He also performed world's 1st Awake Open Heart Surgery (on a 74 year patient who underwent triple bypass with aortic valve replacement without G. or a ventilator) in April 200 He is the founding member of the International Society of Minimally Invasive Cardiac Surgeons(ISMICS) and is the only Indian on the editorial board of its journal, Innovations in Cardiac Surgery. He is also the council member of the Asian Association of Cardiothoracic Surgeons.
Cardiomyocytes, the working muscle cells of the heart, are terminally differentiated cells in the adult organism and regeneration is limited. This is a worrisome fact, since ischemia and cardiotoxic compounds can lead to cell death and irreversible decline of cardiac function. Our group is investigating the cardiotoxicity of old and new cancer therapies on the heart and survival pathways that exist in the organ.
As in vitro model, isolated organs and primary cells from rodents have been the standard in research and toxicology so far, but there is a need for better models. Therefore, we are developing a model comprising both the advantages of scaffold-free 3D cell culture and cardiomyocytes derived from induced pluripotent stem cells (iPSC) of human origin. Myocardial microtissues (MT) are generated by self-assembly in multi-well hanging drop cultures. In the hanging drop cultures, iPSC-derived cardiomyocytes formed MT’s within 4 days, and those were contracting up to 3 weeks and recorded by optical motion tracking. Morphological and functional characterization underline that this model might become a valuable tool for research on the mechanisms of cardiotoxicity of cancer therapies in the future
Cardiovascular disease is the leading cause of death worldwide. As such, there is great interest in identifying novel mechanisms that govern the cardiovascular response to disease-related stress. First described in failing hearts, autophagy within the cardiovascular system has been widely characterized in cardiomyocytes, cardiac fibroblasts, endothelial cells, vascular smooth muscle cells, and macrophages. In all cases, a window of optimal autophagic activity appears to be critical to the maintenance of cardiovascular homeostasis and function; excessive or insufficient levels of autophagic flux can each contribute to heart disease pathogenesis. In this Review, we discuss the potential for targeting autophagy therapeutically and our vision for where this exciting biology may lead in the future.
Investigators in the Division of Cardiology have rigorous research programs focused cardiac myocyte biology. Their research programs examine:
My lab develops new tools to manipulate and assess cell metabolism and mitochondrial function in living systems. Our goal is to improve cellular resistance to environmental stresses and diseases through engineering metabolism.
Our laboratory is interested in identifying and targeting the key regulators of cell metabolism and mitochondrial function for the treatment of cardiovascular and metabolic diseases. We take multidisciplinary approaches to manipulate and interrogate the cellular metabolic network. For example, we perturb the metabolic network by altering its key element using bioengineered cells or animals and determine the metabolic and functional outcomes using multi-nuclear NMR spectroscopy and metabolomics. Using this strategy, we are studying the remodeling of cardiac metabolism during the development of pathological hypertrophy which is an abnormal growth of the heart that eventually leads to heart failure.
Another focus of our research is to develop mitochondria based cell protection. We recently revealed an important role of redox-sensitive protein acetylation in modulating mitochondrial protein interactome that in turn dictates cellular sensitivity to stress. We are now developing novel technologies with our collaborators, e.g. biosensors, quantitative proteomics and high throughput screening, to determine and target the nodal points of mitochondria-originated injury pathways.
PhD (pharmacology), University of Aarhus, Denmark, 1992
MD, West China University of Medical Sciences, 1986
17th April 2020 at J.N.TATA Auditorium,
Indian Institute of Science, Bengaluru, Karnataka, India.
The heart is one of the most important organs in the human body. The heart pumps the blood, which carries all the vital materials which help our bodies function and removes the waste products that we do not need.
The brain requires oxygen and glucose, which, if not received continuously, will cause it to lose consciousness. Muscles need oxygen, glucose and amino acids, the proper ratio of sodium, calcium and potassium salts to contract normally. Glands need sufficient supplies of raw materials from which to manufacture specific secretions. If the heart ever ceases to pump blood, the body begins to shut down and after a very short period of time will die.
Many forms of heart disease can be prevented or treated with healthy lifestyle choices. Yoga practice is the best way to keep the heart healthy. Asana prepares the entire physical functioning of the body, while pranayama improves the physiology of the body.
Standing poses strengthen the cardiac reserve. Forward bends soothes the nerves and brings down the heart rate. Inverted pose improves the contractility. Back bending poses lengthen the cardiac muscle and the septum. This improves the contraction of heart and improves the quality to pump blood in and out. Twisting pose stretches the wall of the heart. The diaphragm is squeezed and the endurance of the heart is increased.
Pranayama, on the other hand, constantly changes the shape of the heart, thereby preventing blockage in the heart. Prana is the vital energy distributed by the nervous channel (Nadis). Pranayama improves the rhythm of the heart. One who practise pranayama consistently can reduce or increase the heart rate at will. Hence, one gains control over the involuntary mechanism of the body.
Yoga can be done by any one at any age at any health problems. The body system is taken care of, with all the internal organs functioning together to improve the cardiovascular efficiency. Any practitioner can benefit from the practice – whether as preventive, improvement or reverting to normal condition.
A daily Yoga practice leads to a healthy lifestyle. It changes the overall character of a practitioner, controls high blood pressure and diabetes. The effect is more significant with a proper diet. Pranayama gives proper relaxation to reduce and manage stress. A conscious breathing rhythm regulates the heart beat.
Swami Vishnudevananda was born in the south Indian state of Kerala on December 31, 1927. After completing school he entered the Engineering Corps of the Indian Army. It was while he was in the army that he first met Swami Sivananda, one of the great saints of modern times.
After being discharged from the army, Swamy Kuttan Nair, as he was then known, was a schoolteacher in his native Kerala for a short while, before leaving his life behind and entering the Sivananda Ashram in Rishikesh in 1947. Within a year, he took the monastic vow (sannyas) with the name of Swami Vishnudevananda.
Swami Sivananda saw in his young disciple special tendencies towards Hatha Yoga. With his training directed towards this discipline he became an expert, mastering many of the most difficult and advanced Hatha Yoga techniques (asanas, pranayamas, mudras, bandhas and kriyas). How did he learn these ancient practices which to a great extent had been lost in modern India? He often said, "My Master touched me and opened my intuitive eye. All this knowledge returned to me from past lives".
Remaining at the Ashram for ten years, he was appointed as the first Professor of Hatha Yoga at the Yoga Vedanta Forest Academy. He held a number of other positions at the Ashram, including personal secretary to Swami Sivananda.
Swami Vishnudevananda remembers his very first contact with Swami Sivananda:
"I first heard about Swami Sivananda in a strange way. Looking in the waste paper basket for a lost paper, I found one small pamphlet called Sadhana Tattwa. His teachings were so simple and straightforward, ‘an ounce of practice is worth a ton of theory.’i
I got a couple of days’ leave of absence from the army and went to see him. There was no kind of religious hypocrisy, no sitting on a tiger skin with ashes smeared all over his body. He had an extraordinary spiritual glow. The second time I saw him, Swami Sivananda was coming up the stairs in my direction.
I didn’t want to have to bow my head to him. I was young and arrogant and never wanted to bow my head to anybody. But it is the tradition that you should bow your head to a holy man. To avoid the situation, I just moved out of his path. Master saw me and headed in my direction. He asked me who I was and where I was coming from. Then he bowed down and touched my feet!! My whole body began to shake violently.
With all my heart, with all my life and love, I learned to bow without any type of reservation. He touched my heart not with miracles or shows of holiness, but with his perfect egoless nature. He didn’t consider that I was just a stupid boy standing there, although I was just that. He touched my heart and broke that egoism in me. I didn’t think anything else in this world would have broken this ego. That was my first lesson, and if I could attain one millionth of the state of egolessness of the Master, it is His Grace."
You are managing your heart health well and doing many of the right things to minimise your heart disease risk. Keep up the good work.
You have a few risks of heart disease. If you have family history, are over 45 or haven’t spoken to your GP recently, book in a time to get a heart health check.
You have some risk factors for heart disease which need to be managed.
There is no single cause of heart disease, but having multiple risk factors may increase your chance of developing it. If you aren’t already talking to your GP about your personal risks, why not book in a time to get a heart health check today.
You have significant risk of heart disease and may already be living with the disease. Check back on the questions where you logged a high number, and identify what changes you might be able to make to your lifestyle to improve your heart health. See your GP regularly to manage your heart disease risks.